Immunology

June 24, 2021
Many cancer patients may need a sequential one-two punch of immunotherapies thumbnail

Many cancer patients may need a sequential one-two punch of immunotherapies

Anti-PD-1 cancer immunotherapies boost the body’s cancer-fighting T cells, but in many patients, suppressive Tfr cells bring that progress to a grinding halt. Credit: La Jolla […]
May 7, 2021
New antibody rationally designed for better tumor inhibition thumbnail

New antibody rationally designed for better tumor inhibition

A higher affinity antibody HA98 was rationally designed based on the CD146/AA98 complex structure and showed better inhibitory effects on tumor growth. (Image by XIE Can) […]
April 16, 2021
Sweat sensor could alert doctors, patients to looming COVID cytokine storm thumbnail

Sweat sensor could alert doctors, patients to looming COVID cytokine storm

A wristwatch-like device measures cytokine levels in passive sweat. Credit: Kai-Chun Lin Early in the COVID-19 pandemic, doctors recognized that patients who developed a “cytokine storm”—a […]
March 20, 2021
Lack of diversity in genomic databases may affect therapy selection for minority groups thumbnail

Lack of diversity in genomic databases may affect therapy selection for minority groups

Micrograph of a plasmacytoma, the histologic correlate of multiple myeloma. H&E stain. Credit: Wikipedia/CC BY-SA 3.0 Low representation of minority groups in public genomic databases may […]
February 2, 2021
Study identifies noncoding RNA involved in immune response and sepsis thumbnail

Study identifies noncoding RNA involved in immune response and sepsis

GAPLINC, a highly conserved long noncoding RNA, modulates the immune response during endotoxic shock. Reducing or eliminating GAPLINC led to enhanced expression of inflammatory genes in […]
January 27, 2021
Race plays a role in children's food allergies thumbnail

Race plays a role in children’s food allergies

Credit: Pixabay/CC0 Public Domain Black children have significantly higher rates of shellfish and fish allergies than white children, confirming that race plays an important role in […]
January 23, 2021
Exercising muscle combats chronic inflammation on its own thumbnail

Exercising muscle combats chronic inflammation on its own

Long, thin, well-defined muscle fibers (top left) are in shambles after prolonged inflammation (top right), but maintain their structure (bottom left) and strength (bottom right) when […]
December 4, 2020
Gasdermin offers insight into coral necrotic death thumbnail

Gasdermin offers insight into coral necrotic death

Cleavage of GSDME by caspase 3. Credit: IOCAS Pyroptosis is a highly inflammatory form of programmed necrotic cell death that acts as a defense mechanism against […]
December 3, 2020
Peanut treatment lowers risk of severe allergic reactions in preschoolers thumbnail

Peanut treatment lowers risk of severe allergic reactions in preschoolers

Exposing children to a small, regular dose of peanuts in a real-world setting (outside of a clinical trial) is effective in reducing the risk of allergic […]
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